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Efficient transportation and delivery of analytes to the surface of optical sensors are crucial for overcoming limitations in diffusion-limited transport and analyte sensing. In this study, we propose a novel approach that combines metasurface optics with optofluidics-enabled active transport of extracellular vesicles (EVs). By leveraging this combination, we show that we can rapidly capture EVs and detect their adsorption through a color change generated by a specially designed optical metasurface that produces structural colors. Our results demonstrate that the integration of optofluidics and metasurface optics enables spectrometer-less and label-free colorimetric read-out for EV concentrations as low as 107EVs/ml, achieved within a short incubation time of two minutes.more » « less
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Hong, Ikjun; Anyika, Theodore; Hong, Chuchuan; Yang, Sen; Ndukaife, Justus C. (, ACS Photonics)
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Hong, Ikjun; Hong, Chuchuan; Tutanov, Oleg S.; Massick, Clark; Castleberry, Mark; Zhang, Qin; Jeppesen, Dennis K.; Higginbotham, James N.; Franklin, Jeffrey L.; Vickers, Kasey; et al (, Nano Letters)
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